History of Functional Neuromaging at Penn  
Penn has contributed many key developments to the field of Neuroimaging including the first human CBF measurements by Kety and Schmidt in the 1940's, the first human PET scanning by Reivich et al. in the 1970's, early work in in vivo NMR and continued innovation in optical spectroscopy by Chance and others, and the first clinical MRI in the Department of Radiology.

In addition to methodological development, Penn hosts a broad range of basic research using neuroimaging in cognitive neuroscience through the recently created Center for Cognitive Neuroscience, in clinical neuroscience through research groups in the Departments of Neurology, Psychiatry, Radiology, and Anesthesiology, and in several other basic and applied areas.

Conception of FDG-PET imaging by A. Alavi and M. Reivich

Biography of Seymour Kety by Louis Sokoloff, both of whom did seminal work in functional imaging at Penn


Penn-designed Device Shows Promise for Individualized Care in Stroke Patients





Research Space


The University of Pennsylvania is situated on a single urban campus less than ½ mile in diameter.An initiative to consolidate research in neuroimaging and brain function on the Penn campus has completed its second phase, and will ultimately result in nearly all neuroimaging investigators being located in newly renovated space centrally located on campus.  The space houses faculty, trainees, seminar space, and some of the available neuroimaging instrumentation. The Neuroscience Neuroimaging Center, Center for Cognitive Neuroscience (CCN), the Center for Neuroscience and Society, the Laboratory for Cognition and Neural Stimulation, the Computational Neuroscience Initiative, the Penn Image Computing and Science Laboratory, and the Center for Biomedical Image Analysis are now co-located in 30,000 ft2 of newly renovated space in the Richards and Goddard Laboratories, with additional clinical neuroscience laboratories in Psychology, Neurology, and Psychiatry scheduled to move there in the subsequent phase, scheduled for completion in 2018.  The newly-formed Penn Institute for Biomedical Informatics is also housed in the same complex, and will include a new visualization laboratory.  The  Richards and Goddard Laboratories Buildings are a designated National Historic Landmark and were designed by renowned architect Louis Kahn to facilitate research interactions. The majority of NNC personnel.  A new Neural and Behavioral Science building was completed in 2016, and is approximately 50 yards from Richards and Goddard.  This building houses additional cogntive neuroscience faculty and our Mock MRI.  MRI scanners supported by the NNC (see Major Research Instrumentation) are located in nearby buildings including the Stellar-Chance Laboratory (3T and 7T whole body MRI), the Hospital of the University of Pennsylvania (3T whole body MRI), the John Morgan Building (9.4T preclinical MRI), and the Smilow Translational Research Laboratory (3T whole body preclinical MRI).  The relative location of these facilities is indicated on the map below.


University of Pennsylvania Campus showing the location of major program resources.


The Perelman School of Medicine. The Perelman School of Medicine (PSOM) prides itself on the vision that education should be oriented toward combining theory and practice for the betterment of humanity. Penn can rightfully be called the “birthplace of American medicine,” as it includes the nation's first hospital (Pennsylvania Hospital in 1751), first medical school (1765), first university hospital (HUP in 1874), and first integrated academic health system (1993). Penn’s PSOM is ranked second of the nation’s research-oriented medical schools (US News and World Report). Penn’s comprehensive health care system includes HUP, which is featured in US News & World Report’s Best Hospitals in America guide, and extensive primary and specialty networks, Penn-Presbyterian Medical Center and Pennsylvania Hospital, as well as the clinical practices. Children’s Hospital of Philadelphia (CHOP), an affiliated hospital, is the nation’s top-ranked pediatric hospital (2006 Child Magazine, 2006 US News and World Report). The PSOM has a distinguished faculty, including 9 members of the National Academy of Sciences (27 at Penn altogether) and 75 members of the Institute of Medicine (IOM); and a major research facility of the Howard Hughes Medical Institute, with a total of six investigators in the PSOM. The PSOM, integrated within the University of Pennsylvania Health System (UPHS), is committed to advancing its status as a world-leading institution in its three equally valued and inter-related missions of patient care, research, and education.


Collaborating Schools and Institutions. PSOM is colocated with the rest of the University of Pennsylvania on a single urban campus.  This greatly facilitates collaboration and participation across Penn Schools.  The Neuroscience Neuroimaging Program includes users from the School of Arts and Sciences (Psychology, Physics), the School of Engineering and Applied Science (Bioengineering), the Annenberg School for Communication (Communications Neuroscience), the Veterinary School (Animal Neuroscience), and the Wharton School (Behavioral Economics).  Nearby collaborating institutions include Children’s Hospital of Philadelphia (adjacent), Drexel University (adjacent), Temple University (4 miles), and the Moss Rehabilitation Research Institute (13 miles).